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期刊
- 作者： Xianghua Quan, Qie Guo, Xiangpeng Li, Yu Liang, Mengna Cui, Jing Li, Shan Huang, Jule Wang, Bin Li （ Affiliations 1 Department of Pharmacy, Affiliated Hospital of Qingdao University, Qingdao, China. 2 Key Laboratory of Pharmaceutical Research for Metabolic Diseases, Department of Pharmacy, Qingdao University of Science & Technology, Qingdao, China. 3 Key Laboratory of Pharmaceutical Research for Metabolic Diseases, Department of Pharmacy, Tibet University, Lhasa, China. ）
- 出处： Journal of food biochemistry 2022 Pe14134
- 关键词： HepG2 Malus toringoides Hughes glucose and lipid metabolism hepatic steatosis high fructose mice.
- 摘要： Malus toringoides Hughes, as a traditional medicinal and edible plant used in Tibet, China, is used to treat hypertension, hyperlipidemia, and liver
期刊
- 作者： Quan, Xianghua，Guo, Qie，Li, Xiangpeng，Liang, Yu，Cui, Mengna，Li, Jing，Huang, Shan，Wang, Jule，Li, Bin （ 1 Department of Pharmacy, Affiliated Hospital of Qingdao University 2 Key Laboratory of Pharmaceutical Research for Metabolic Diseases, Department of Pharmacy, Qingdao University of Science & Technology 3 Key Laboratory of Pharmaceutical Research for Metabolic Diseases, Department of Pharmacy, Tibet University ）
- 出处： Journal of Food Biochemistry 2022 P1
- 关键词： glucose and lipid metabolism hepatic steatosis HepG2 high fructose Malus toringoides Hughes mice
- 摘要： Practical applications Malus toringoides Hughes, as a traditional medicinal and edible plant used in Tibet, China, is used to treat hypertension, hyp
期刊
- 作者： Xianghua Quan, Qie Guo, Xiangpeng Li, Yu Liang, Mengna Cui, Jing Li, Shan Huang, Jule Wang, Bin Li （ Affiliations 1 Department of Pharmacy, Affiliated Hospital of Qingdao University, Qingdao, China. 2 Key Laboratory of Pharmaceutical Research for Metabolic Diseases, Department of Pharmacy, Qingdao University of Science & Technology, Qingdao, China. 3 Key Laboratory of Pharmaceutical Research for Metabolic Diseases, Department of Pharmacy, Tibet University, Lhasa, China. ）
- 出处： Journal of food biochemistry 2022 Vol.46 No.7 Pe14134
- 关键词： HepG2 Malus toringoides Hughes glucose and lipid metabolism hepatic steatosis high fructose mice.
- 摘要： Malus toringoides Hughes, as a traditional medicinal and edible plant used in Tibet, China, is used to treat hypertension, hyperlipidemia, and liver
期刊
- 作者： Quan, Xianghua，Guo, Qie，Li, Xiangpeng，Liang, Yu，Cui, Mengna，Li, Jing，Huang, Shan，Wang, Jule，Li, Bin （ aDepartment of Pharmacy, Affiliated Hospital of Qingdao University, Qingdao, China;bKey Laboratory of Pharmaceutical Research for Metabolic Diseases, Department of Pharmacy, Qingdao University of Science & Technology, Qingdao, China;cKey Laboratory of Pharmaceutical Research for Metabolic Diseases, Department of Pharmacy, Tibet University, Lhasa, China ）
- 出处： Journal of Food Biochemistry 2022
- 关键词： glucose and lipid metabolism hepatic steatosis HepG2 high fructose Malus toringoides Hughes mice
- 摘要： Malus toringoides Hughes, as a traditional medicinal and edible plant used in Tibet, China, is used to treat hypertension, hyperlipidemia, and liver
- 作者： 泽仁拉姆，央卓玛，袁瑞瑛，卓玛东智，王聚乐，周毛措 （ 西藏大学 ）
- 出处： 西藏医药 2022 第2期 P145-147
- 关键词： 罗堆多吉颗粒 醇提水沉 正交试验 高效液相色谱
- 摘要： 目的优化罗堆多吉颗粒的提取纯化工艺。方法以木犀草素、甘松新酮含量及浸膏得率的综合评分为指标,采用正交试验法考察乙醇浓度、料液比和时间对醇提工艺的影响,并优选了水沉工艺中加水量、药液相对密度、静置时间等因素。结果最佳醇提工艺为8倍量80%乙醇,提取2次,每次2h;最佳水沉工艺为加水量40倍,药液相对密
期刊
- 作者： Minzhu Wang, Dongzhi Zhuoma, Ruiying Yuan, Yuefei Wang, Zhen Pu, Lamu Zeren, Jule Wang, Meng Tan, Shan Huang （ Affiliations 1 Department of Pharmacy, Key Laboratory of Pharmaceutical Research for Metabolic Diseases, Qingdao University of Science & Technology, Qingdao China. 2 Department of Medicament, College of Medicine, Tibet University, Lhasa China/ Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla Thailand. 3 Department of Medicament, College of Medicine, Tibet University, Lhasa China/ Center of Tibetan Studies (Everest Research Institute), Tibet University, Lhasa China. 4 Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, China. 5 Department of Medicament, College of Medicine, Tibet University, Lhasa China. ）
- 出处： Pakistan journal of pharmaceutical sciences 2022 Vol.35 No.4 P1015-1021
- 摘要： As a popular medicinal plant traditionally used in Tibet of China, Nepeta angustifolia C. Y. Wu is mainly administered to treat apoplexia, cerebral ha
- 作者： 袁瑞瑛，普珍，王敏竹，范成德，李斌，卓玛东智，王聚乐 （ 西藏大学；武汉大学；青岛科技大学 ）
- 出处： 中医药导报 2022 第10期
- 关键词： 高尿酸血症 藏党参 尿酸转运体 黄嘌呤氧化酶 小鼠
- 摘要： 目的：探究藏党参提取物对酵母膏联合氧嗪酸钾诱导的高尿酸血症小鼠的治疗作用及保护机制。方法：将60只雄性昆明种小鼠按随机数字表法分为空白组、模型组、藏党参提取物低剂量组、藏党参提取物中剂量组、藏党参提取物高剂量组、别嘌醇组，每组10只。除空白组外，其余小鼠每日灌胃给予酵母膏，持续14 d。在造模同时，
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期刊
- 作者： Fan, Chengde，Dongzhi, Zhuoma，Dong, Linsha，Yuan, Ruiying，Wang, Jule，Li, Bin，Huang, Shan （ 1 Department of Pharmacy, Key Laboratory of Pharmaceutical Research for Metabolic Diseases, Qingdao University of Science and Technology, Qingdao 2 Department of Medicament, College of Medicine, Tibet University, Lhasa, China, Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, Thailand 3 Department of Medicament, College of Medicine, Center of Tibetan Studies (Everest Research Institute), Tibet University, Lhasa 4 Department of Medicament, College of Medicine, Tibet University, Lhasa ）
- 出处： Pharmacognosy Magazine 2021 Vol.17 No.75 P518-524
- 关键词： Human umbilical vein endothelial cells Malus toringoides Hughes mitogen-activated protein kinases nuclear factor erythroid 2-related factor 2/heme oxygenase-1
- 摘要： Background: Malus toringoides Hughes is a traditional Tibetan medicine. It demonstrates significant hypoglycemic and hypolipidemic potential. However
- 作者： 泽仁拉姆，袁瑞瑛，李鑫宇，范成德，黄山，卓玛东智，王聚乐，普珍 （ 西藏大学医学院；武汉大学药学院；青岛科技大学化工学院 ）
- 出处： 中药新药与临床药理 2021 第32卷 第11期 P1632-1639
- 关键词： 藏荆芥 乙醇提取物 巨噬细胞RAW264.7 小鼠 炎症 NF-κB
- 摘要： 目的研究藏荆芥乙醇提取物对脂多糖诱导的体内外炎症模型的作用及其作用机制。方法将小鼠随机分为空白对照组、脂多糖模型组、阳性药地塞米松组及藏荆芥乙醇提取物低、中、高剂量组,每组10只。通过腹腔注射脂多糖建立小鼠急性腹膜炎模型,采用酶联免疫法检测各组小鼠腹腔灌洗液中炎症因子水平。另外,通过脂多糖诱导小鼠巨
- 作者： 严岑，王秋贺，王静宜，常柄权，黄山，李斌，王聚乐 （ 青岛科技大学化工学院；西藏大学医学院 ）
- 出处： 中华中医药学刊 2020 第1期 P140-143
- 关键词： 藏荆芥 四氧嘧啶 糖尿病模型 降血糖
- 摘要： 目的研究藏荆芥提取物对四氧嘧啶诱导糖尿病模型小鼠降血糖作用。方法采用腹腔注射四氧嘧啶建立小鼠糖尿病模型,实验分为空白对照组、模型组、阳性对照组、藏荆芥提取物高、中、低剂量组,测定小鼠体质量、血糖、糖耐受量和脏器指数指标,试剂盒检测血清超氧化物歧化酶、一氧化氮及肝脏丙二醛、谷胱甘肽过氧化物酶、总胆固醇