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5-(4-Hydroxyphenyl)-3H-1,2-dithiole-3-thione-based fibrates as potential hypolipidemic and hepatoprotective agents.

  • 【作者】Zi-Zhang Chen,Yun-Dong Xie,Li-Hua Shao,Qiu-Tang Wang,Yan-Hong Xu,Xiao-Li Bian
  • 【DOI】10.1016/j.bmcl.2018.10.003
  • 【作者单位】College of Pharmacy, Xi\'an Jiaotong University, No.76 Yanta West Road, Xi\'an, Shaanxi Province 710061, People\'s Republic of China. College of Pharmacy, Xi\'an Jiaotong University, No.76 Yanta West Road, Xi\'an, Shaanxi Province 710061, People\'s Republic of China;Department of Medicine, Tibet University of Nationalities, No.6 Wenhui East Road, Xianyang, Shaanxi Province 712082, People\'s Republic of China. Electronic address: xieshijiada405@stu.xjtu.edu.cn. College of Pharmacy, Xi\'an Jiaotong University, No.76 Yanta West Road, Xi\'an, Shaanxi Province 710061, People\'s Republic of China. Electronic address: bianxl@mail.xjtu.edu.cn.
  • 【年份】2018
  • 【卷号】Vol.28 No.23-24
  • 【页码】3787-3792
  • 【ISSN】1464-3405
  • 【关键词】Fibrates Hepatoprotection Hypolipidemic 
  • 【摘要】 Hypolipidemic effects of the newly synthesized 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione-based fibrates were evaluated in Triton WR-1339 and high-fat diet (HFD)-induced hyperlipidemic mice. Preliminary screening of all the synthesized compounds wa...
  • 【文献类型】 期刊
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