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Antidepressant Effects of 3--2E-propenoic Acid Isobutyl Amide Involves TSPO-mediated Mitophagy Signalling Pathway

  • 【作者】Qiang Wei, Wangyi Zhou, Ji Zheng, Dongmei Li, Mingyang Wang, Lu Feng, Wei Huang, Nan Yang, Min Han, Xiaohui Ma, Yanyong Liu
  • 【作者单位】Affiliations 1 Medical College, Tibet University, Tibet Autonomous Region, Lhasa, 850000, China. 2 Pharmacology and Toxicology Research Centre, Tasly Institute, Tasly Holding Group Co., Ltd, Tianjin, 300410, China. 3 Department of Pharmacology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.
  • 【年份】2020
  • 【ISSN】1742-7843
  • 【关键词】Piper laetispicum depression learned helplessness mitochondria mitophagy social defeat stress. 
  • 【摘要】 Piper laetispicum C.DC is one of Chinese Herbal Medicine used for alleviating depressive disorders. G11-5 [3--2E-propenoic acid isobutyl amide] is synthesized based on the chemical structure of an active integrant of Piper laetispicum C.DC. The prese...
  • 【文献类型】 期刊
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