Nfa34810 facilitates Nocardia farcinica invasion of host cells and stimulates TNF-α secretion through activation of the NF-κB and MAPK pathways via TLR4.
【作者单位】State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. School of Laboratory Medicine and Life Sciences, Wenzhou Medical University,Wenzhou, Zhejiang, China. Department of Medicine, Tibet University, Lhasa, Tibet, China. State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China lizhenjun@icdc.cn.
【年份】2020
【ISSN】1098-5522
【摘要】 The mechanism underlying the pathogenesis of Nocardia is not fully known. The Nfa34810 protein of Nocardia farcinica has been predicted to be a virulence factor. However, relatively little is known regarding the interaction of Nfa34810 with host cell...
