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Inhibition of Transient Receptor Potential Vanilloid 4 Mitigates Seizures

  • 【作者】Meng-Liu Zeng, Jing-Jing Cheng, Shuo Kong, Xing-Liang Yang, Xiang-Lei Jia, Xue-Lei Cheng, Ling Chen, Fang-Gang He, Yu-Min Liu, Yuan-Teng Fan, Lanzi Gongga, Tao-Xiang Chen, Wan-Hong Liu, Xiao-Hua He, Bi-Wen Peng
  • 【作者单位】Affiliations 1 Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Donghu Rd185#, 430071, Wuhan, Hubei, China. 2 Institute of Forensic Medicine, School of Basic Medical Sciences, Wuhan University, 430071, Wuhan, Hubei, China. 3 Department of Neurology, Zhongnan Hospital, Wuhan University, Donghu Road 169#, 430071, Wuhan, Hubei, China. 4 Tibet University Medical College, 850000, Lhasa, Tibet, China. 5 Department of Immunology, School of Basic Medical Sciences, Wuhan University, 430071, Wuhan, Hubei, China. 6 Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, 430071, Wuhan, Hubei, China. 7 Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Donghu Rd185#, 430071, Wuhan, Hubei, China. pengbiwen@whu.edu.cn.
  • 【年份】2022
  • 【ISSN】1878-7479
  • 【关键词】4-Aminopyridine Astrocyte Inflammation Seizures TRPV4. 
  • 【摘要】 Astrocytes are critical regulators of the immune/inflammatory response in several human central nervous system diseases. Emerging evidence suggests that dysfunctional astrocytes are crucial players in seizures. The objective of this study was to inv...
  • 【文献类型】 期刊
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