Disrupted gut microbiota aggravates spatial memory dysfunction induced by high altitude exposure: A link between plateau environment and microbiome-gut-brain axis
【作者单位】Affiliations 1 Plateau Brain Science Research Center, Tibet University, Lhasa, Tibet, China. 2 Baiyun Branch, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. 3 Baiyun Branch, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Guangzhou Beneco biotechnology Co. Ltd., Guangzhou, Guangdong, China. 4 Animal Microecology Institute, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China. 5 Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. 6 Baiyun Branch, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. 7 Baiyun Branch, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. Electronic address: kanne111@163.com. 8 Baiyun Branch, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. Electronic address: sunasa1030@foxmail.com. 9 Plateau Brain Science Research Center, Tibet University, Lhasa, Tibet, China. Electronic address: David_ma79@163.com.
【年份】2023
【卷号】Vol.259
【页码】115035
【ISSN】1090-2414
【关键词】Antibiotics High altitude environment Microbiome-gut-brain axis Probiotics Spatial memory dysfunction.
【摘要】 Approximately 400 million people work and live in high-altitude areas and suffer from memory dysfunction worldwide. Until now, the role of the intestinal flora in plateau-induced brain damage has rarely been reported. To address this, we investigated...
