【作者】Hui Yuan，Jiaqi Wu，Xiaoqiang Wang，Jiakuan Chen，Yang Zhong，Qiang Huang，Peng Nan
【DOI】10.3389/fpls.2017.00248
【作者单位】[ 1 ] Fudan Univ, Sch Life Sci, Key Lab Biodivers Sci & Ecol Engn, Minist Educ, Shanghai, Peoples R China [ 2 ] Univ North Texas, Dept Biol Sci, Denton, TX USA [ 3 ] Tibet Univ, Inst Biodivers Sci & Geobiol, Lhasa, Peoples R China [ 4 ] Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai, Peoples R China
【年份】2017
【卷号】Vol.8
【页码】248
【ISSN】1664-462X
【关键词】chalcone–flavonone isomerase enzyme engineering molecular modeling positive selection protein design
【摘要】 Protein design for improving enzymatic activity remains a challenge in biochemistry, especially to identify target amino-acid sites for mutagenesis and to design beneficial mutations for those sites. Here, we employ a computational approach that comb...
