Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19

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【作者】Xiaoyan Liu，Zhe Li，Shuai Liu，Jing Sun，Zhanghua Chen，Min Jiang，Qingling Zhang，Yinghua Wei，Xin Wang，Yi-You Huang，Yinyi Shi，Yanhui Xu，Huifang Xian，Fan Bai，Changxing Ou，Bei Xiong，Andrew M.Lew，Jun Cui，Rongli Fang，Hui Huang，Jincun Zhao，Xuechuan Hong，Yuxia Zhang，Fuling Zhou，Hai-Bin Luo
【作者单位】Department of Hematology，Zhongnan Hospital of Wuhan University，Wuhan 430071，China；Guangdong Provincial Key Laboratory of New Drug Design and Evaluation，School of Pharmaceutical Sciences，Sun Yat-sen University，Guangzhou 510006，China；Dawu County People's Hospital，Xiaogan 432826，China；State Key Laboratory of Respiratory Diseases，National Clinical Research Center for Respiratory Disease，Guangzhou Institute of Respiratory Health，The First Affiliated Hospital of Guangzhou Medical University，Guangzhou 510120，China；Guangzhou Institute of Pediatrics，Guangzhou Women and Children's Medical Center，State Key Laboratory of Respiratory Diseases，Guangzhou Medical University，Guangzhou 510623，China；Biomedical Pioneering Innovation Center (BIOPIC)，School of Life Sciences，Peking University，Beijing 100871，China；Department of Infectious Disease and Department of Pediatrics，The First Affiliated Hospital of Guangxi Medical University，Nanning 530021，China；Center for Innovative Marine Drug Screening & Evaluation (QNLM)，School of Medicine and Pharmacy，Ocean University of China，Qingdao 266100，China；Walter and Eliza Hall Institute of Medical Research and Department of Microbiology & Immunology，University of Melbourne，Parkville，Vic 3052，Australia；School of Life Sciences，Sun Yat-sen University，Guangzhou 510006，China；Cardiovascular Department，The Eighth Affiliated Hospital，Sun Yat-sen University，Shenzhen 518000，China；State Key Laboratory of Virology，College of Science，Innovation Center for Traditional Tibetan Medicine Modernization and Quality Control，Medical College，Tibet University，Lhasa 850000，China；Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE)，Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals，Wuhan University School of Pharmaceutical Sciences，Wuhan 430071，China
【年份】2020
【卷号】第10卷
【期号】第7期
【页码】1205-1215
【关键词】Dipyridamole SARS-CoV-2 COVID-19 Treatment D-dimer Severe cases
【摘要】 Severe acute respiratory syndrome coronavirus 2 infection can cause acute respiratory distress syndrome,hypercoagulability,hypertension,and multiorgan dysfunction.Effective antivirals with safe clinical profile are urgently needed to improve the ove...
【文献类型】期刊

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