Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels

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【获取途径】 OA资源
【作者】Qu, Chunrong，Ding, Mingmin，Zhu, Yingmin
【作者单位】; 1 Wuhan Univ, Sch Pharmaceut Sci, Key Lab Combinatorial Biosynth & Drug Discovery M, State Key Lab Virol, Wuhan 430071, Hubei Province, Peoples R China ; 2 Wuhan Univ, Sch Pharmaceut Sci, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Wuhan 430071, Hubei Province, Peoples R China ; 3 Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Integrat Biol & Pharmacol, Houston, TX 77030 USA ; 4 Anhui Med Univ, Sch Basic Med Sci, Hefei 230032, Anhui Province, Peoples R China ; 5 Johns Hopkins Univ, Sch Med, High Throughput Biol Ctr, Dept Neurosci, Baltimore, MD 21205 USA ; 6 Johns Hopkins Univ, Sch Med, Johns Hopkins Ion Channel Ctr, Baltimore, MD 21205 USA ; 7 China Pharmaceut Univ, Jiangsu Prov Key Lab TCM Evaluat & Translat Dev, State Key Lab Nat Med, Nanjing 211198, Jiangsu, Peoples R China ; 8 Chinese Acad Sci, Shanghai Inst Mat Med, Int Scientist Working Stn Neuropharmacol, Shanghai 201203, Peoples R China ; 9 Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; 10 Tibet Univ, Coll Med, Lasa 850000, Tibet, Peoples R China ; 11 Chinese Acad Sci, Kunming Inst Bot, Key Lab Phytochem & Plant Resources West China, Kunming 650201, Yunnan Province, Peoples R China ; 12 Yantai Univ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Minist Educ, Yantai 264005, Shangdong Provi, Peoples R China ; 13 Univ Calif Berkeley, Berkeley, CA 94720 USA ; 14 Univ Iowa, High Throughput Screening Facil, Iowa City, IA 52242 USA ; 15 Essen Biosci, Ann Arbor, MI 48108 USA ; 16 GlaxoSmithKline, Philadelphia, PA 19103 USA ; 17 Southwest Med Univ, Luzhou 646000, Sichuan, Peoples R China
【年份】2017
【卷号】Vol.60 No.11
【页码】4680-4692
【ISSN】0022-2623
【关键词】TRPC6 CHANNELS SMALL-MOLECULE CARDIAC-HYPERTROPHY CATION CHANNEL CELLS INHIBITORS CALCIUM DIACYLGLYCEROL IDENTIFICATION HYPERTENSION
【摘要】 Transient receptor potential canonical 3/6/7 are highly homologous receptor-operated nonselective cation channels. Despite their physiological significance, very few selective and potent agonists are available for functional examination of these cha...
【文献类型】期刊

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