Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats

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【作者】Wang T.，Liu Y.，Chen L.，Wang X.，Hu X.-R.，Feng Y.-L.，Liu D.-S.，Xu D.，Duan Y.-P.，Lin J.，Ou X.-M.，Wen F.-Q.
【DOI】10.1183/09031936.00055908
【作者单位】Division of Pulmonary Diseases, Dept of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan Dept of Biochemistry, Tibet University, Medical College Lhasa, Tibet, China Division of Pulmonary Diseases, Dept of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 61004, China
【年份】2009
【卷号】Vol.33 No.5
【页码】1122-1132
【ISSN】0903-1936
【关键词】Airway inflammation Cyclic guanosine 3,5-monophosphate Goblet cell metaplasia Mucin synthesis Phosphodiesterase-5 inhibitor
【摘要】 Airway inflammation with mucus overproduction is a distinguishing pathophysiological feature of many chronic respiratory diseases. Phosphodiesterase (PDE) inhibitors have shown anti-inflammatory properties. In the present study, the effect of sildena...
【文献类型】期刊