Nemo-like kinase (NLK) primes colorectal cancer progression by releasing the E2F1 complex from HDAC1

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【作者】Shang-Ze Li，Feng Zeng，Jun Li，Qi-Peng Shu，Hui-Hui Zhang，Jun Xu，Jian-Wei Ren，Xiao-Dong Zhang，Xue-Min Song，Run-Lei Du，
【DOI】10.1016/j.canlet.2018.05.032
【作者单位】Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China Research Centre of Anesthesiology and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei, China College of Medicine, Hunan Normal University, Changsha, Hunan, China Tibet University Medical College, Lasha, Tibet, China
【年份】2018
【卷号】Vol.431
【页码】43-53
【ISSN】0304-3835
【关键词】Cell cycle Colorectal cancer E2F1 HDAC1 NLK
【摘要】 Control of E2F1 activity is restricted via its interactions with RB1 and HDAC1. However, the detailed regulatory mechanisms underlying the E2F1/HDAC1 complex remain elusive. Here, we report that Nemo-like kinase (NLK) boosts cell cycle progression, w...
【文献类型】期刊