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Antidepressant effects of 3--2E-propenoic acid isobutyl amide involves TSPO-mediated mitophagy signalling pathway.

  • 【作者】Qiang,Wei ,Wangyi,Zhou ,Ji,Zheng ,Dongmei,Li ,Mingyang,Wang ,Lu,Feng ,Wei,Huang ,Nan,Yang ,Min,Han ,Xiaohui,Ma ,Yanyong,Liu
  • 【作者单位】Medical College, Tibet University, Tibet Autonomous Region, Lhasa, 850000, China. '(1)' ; Pharmacology and Toxicology Research Centre, Tasly Institute, Tasly Holding Group Co., Ltd, Tianjin, 300410, China. [2] ; Department of Pharmacology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China. [3]
  • 【关键词】Piper laetispicum depression learned helplessness mitochondria mitophagy social defeat stress 
  • 【摘要】 Piper laetispicum C.DC is one of Chinese Herbal Medicine used for alleviating depressive disorders. G11-5 [3--2E-propenoic acid isobutyl amide] is synthesized based on the chemical structure of an active integrant of Piper laetispicum C.DC. The prese...
  • 【文献类型】 期刊
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