Engineering Biomimetic Biosensor Using Dual-Targeting Multivalent Aptamer Regulated 3D DNA Walker Enables High-Performance Detection of Heterogeneous Circulating Tumor Cells
【作者】Lanlan Jia，Qi Hu，Tingting Zhang，Zhaojia Wang，Dan Wu，Xiaoyu Xie，Sicen Wang
【作者单位】Affiliations 1 School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, P. R. China. 2 Shaanxi Engineering Research Center of Cardiovascular Drugs Screening & Analysis, Xi'an, 710061, P. R. China. 3 School of Medicine, Tibet University, Lhasa, 850000, P. R. China.
【摘要】 The phenotypic heterogeneity of circulating tumor cells and the nonspecific adsorption of background cells impede the effective and sensitive detection of rare CTCs. Although leukocyte membrane coating approach has a good antileukocyte adhesion abil...
